Having played the role of Dr. Alexandra “Lexie” Grey in the medical drama TV series, Grey’s Anatomy. During mid-2020, Leigh contracted COVID-19 and became ill. Leigh described her experience in an article published to createchange.me on October 14, 2020: Alongside Stephen Dorff, JR Bourne, and Tom Berenger, she co-starred as Molly Reins in the 2012 thriller film, Brake. Okay. It’s taken a lot of years to get here & I’m sorry for that truly but ya’ll need to know that @iJesseWilliams is a #fraud! This guys been manipulating women for way too long. I know ya’ll gonna think I’m wrong cuz ya’ll love #GreysAnatomy but #truth [sic].

In 2015, she started appearing as Alex Danvers, Kara’s human adoptive sister who is a physician, scientist, and government agent serving as Hank Henshaw’s right-hand at the DEO, in the superhero adventure drama series, Supergirl. Leigh also notes that it was “really important for [Azie and I] to get it right and to not to fight for it, but to really push to make sure that there’s enough coverage of them and representation for the show, and to show a healthy relationship. We know that the fans really appreciated that, and you do get to see a lot more of that for the rest of the season — the two of them in a healthy relationship.” The original filming schedule set Melissa Benoist, who stars as the titular superheroine, as the last person to shoot so that she could deliver a big speech at the end. However, Leigh, Benoist and David Harewood pushed to rearrange the schedule so that all three OG cast members would close out the last day of filming together.

Benoist: To me, Alex was always a superhero, so it only made sense that she got her suit and her Hand of the Soldier gauntlet [ which transforms into any weapon she desires]. Like, it’s about time. And with David Harewood [Martian Manhunter] — the three of us are the OGs from the very get-go — it’s so solid that any of us can step out and the show is in good hands. Supergirl,' 'Grey's Anatomy' Star Chyler Leigh Comes Out". June 8, 2020. Archived from the original on June 8, 2020 . Retrieved June 9, 2020. Supergirl and Grey's Anatomy star Chyler Leigh comes out in moving essay about her journey with her sexuality". June 9, 2020. Archived from the original on July 1, 2020 . Retrieved August 10, 2021. Chyler, you were a mom first, and Melissa, you directed the show first. Did you two trade notes on either? Bialas, Michael (June 27, 2011). "Playing Doctor: A House Call From Chyler Leigh of Grey's Anatomy". Huffington Post. Archived from the original on August 18, 2012 . Retrieved June 3, 2012.

Chyler Leigh also makes music with her husband Nathan West (East of Eli), under the name "WestLeigh". They have performed covers and originals songs. In 2015, for their thirteenth anniversary they wrote "Love Lit The Sky". [3] On Saint Valentine's Day 2017 they released a single "Nowhere" and then she take part in tours. [4] [5] [6] [7] In 2002, she was placed in the 65 th position in the “Hot 100 Women of 2002” list created by Maxim magazine. Everybody has been thinking the girl from the 1800s that we introduced in the pilot is Alice. And so, I love that moment, the sweep the rug out of everybody's feet moment, when we reveal it's actually Kat. We were a hot mess,” Leigh recalls of those final days of shooting. “Everybody’s crying. Everybody’s grateful and so appreciative…. Each day, you’re saying goodbye to somebody.”Regarding diet, she tries to make healthy choices. She relies largely on a vegetarian diet with a focus on eating fresh veggies. She occasionally eats poultry and fish for her protein intake. She has also given Blood Type Diet a try as well. In this diet plan, the blood test is done and then a customized diet plan is made accordingly. Chyler Leigh Favorite Things Spirit of Samba (feat. Nina Miranda, Chyler Leigh, Luisa Maita & Eloisa) - Single di Laurent Voulzy". June 18, 2017. Archived from the original on October 29, 2019 . Retrieved October 29, 2019– via music.apple.com. Chyler Leigh still waiting for prime time to be kind". Virginian-Pilot Archives. November 14, 2005. Archived from the original on June 3, 2019 . Retrieved June 4, 2019. On the eve of their 13 th anniversary, they created the single, Love Lit the Sky. They released another single Nowhere on Valentine’s eve in 2017. First Film Supergirl's Chyler Leigh on Turning Vigilante and the Critical Finale Ending". E! News. May 17, 2020. Archived from the original on June 9, 2020 . Retrieved June 9, 2020.