Molecular Biology of the Cell 5E

Product Information

Now in it’s 6th edition, Molecular Biology of the Cell(MBoC), a classic university biology textbook, and it’s lighter companion book, Essential Cell Biology (in its 4th edition), continue to offer students a “new and invigorating outlook on what cells are and what they do.” Initiation at AUG Codons Upstream of the Translation Start Can Regulate Eucaryotic Translation Initiation Egg-Polarity, Gap, and Pair-Rule Genes Create a Transient Pattern That Is Remembered by Other Genes

Combinations of Start-Transfer and Stop-Transfer Signals Determine the Topology of Multipass Transmembrane ProteinsTransport Between the Nucleus and Cytosol Can Be Regulated by Controlling Access to the Transport Machinery

Electron-transport Chains Enabled Anaerobic Bacteria to Use Nonfermentable Molecules as Their Major Source of Energy The Plasma Membrane Contains Lipid Rafts That Are Enriched in Sphingolipids, Cholesterol, and Some Membrane Proteins The Photosynthetic Electron-transport Chains of Cyanobacteria Produced Atmospheric Oxygen and Permitted New Life-Forms An Egg Is Highly Specialized for Independent Development, with Large Nutrient Reserves and an Elaborate Coat A mere high-level listing of a sampling of subjects covered such as this cannot do justice to all the admirable features of Alberts’ text. In every case, the exposition of a process involves not just a summary of its purpose and how it functions, but names the individual molecular species that participate in it and outlines the mechanism by which they interact, where known, which is most often the case. Well designed schematic figures, diagrams, tables and photographs illustrate in pictures what is said in the text and considerably facilitate understanding. Confronted with such an overwhelming wealth of material, we can only call out a few characteristic and particularly striking points in the authors’ exposition:

Regulatory Proteins Control the Activity of GTP-Binding Proteins by Determining Whether GTP or GDP Is Bound Conditional and Induced Somatic Mutations Make it Possible to Analyze Gene Functions Late inDevelopment Authors: Bruce Albert, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

Ideal for libraries, laboratories, and researchers, this Reference Edition of Molecular Biology of the Cell, Fifth Edition offers an alternative to the student version by providing the complete text of Chapters 1-25 in printed format.* Oocyte growth and egg cleavage in Xenopus. The oocyte grows without dividing for many months in the ovary of the mother frog and finally matures into an egg. Upon fertilization, the egg cleaves very rapidly—initially at a rate of one division (more...) Epithelial Cells Have Two Distinct Early Endosomal Compartments But a Common Late Endosomal Compartment The RecA Protein and its Homologs Enable a DNA Single Strand to Pair with a Homologous Region of DNA Double Helix

Excerpt

Metal Shadowing Allows Surface Features to Be Examined at High Resolution by Transmission Electron Microscopy Nucleic Acid Hybridization Reactions Provide a Sensitive Way of Detecting Specific Nucleotide Sequences Despite their outward differences, the two yeast species share a number of features that are extremely useful for genetic studies. They reproduce almost as rapidly as bacteria and have a genome size less than 1% that of a mammal. They are amenable to rapid molecular genetic manipulation, whereby genes can be deleted, replaced, or altered. Most importantly, they have the unusual ability to proliferate in a haploid state, in which only a single copy of each gene is present in the cell. When cells are haploid, it is easy to isolate and study mutations that inactivate a gene, as one avoids the complication of having a second copy of the gene in the cell. Highly Condensed Chromatin Replicates Late, While Genes in Less Condensed Chromatin Tend to Replicate Early